23VITALS™ FAQs – 23Vitals

Frequently Asked Questions

Product Use

What is the best way to take 23Vitals?

Follow suggested use on the label by mixing ½ to 1 full scoop in 8 – 16 ounces of filtered water, yogurt, a smoothie, or shake. If you enjoy a more neutral flavor, feel free to add it to a larger shaker, 20 - 32oz - mix well and enjoy. We recommend you take 23Vitals anytime it's convenient, in the morning after breakfast, midday after lunch, or you can use it as a during or post physical activity drink - to promote optimal immune health.

Are there any allergy concerns with this product?

We suggest you check with your healthcare provider before use if you have a food allergy. This product contains milk protein components that positively impact the immune and cardiopulmonary systems, but if you have a true milk allergy, you should avoid using it.

This product is gluten-free and still suitable for a low-lactose diet. This product is gluten-free and even ideal for a low-lactose diet.

Is this product meant to be taken year-round?

YES! Everyday lifestyle stressors can impact our immune health year-round. Our hope that incorporating 23Vitals into your daily routine will also bring more awareness to the things that may be affecting your stress levels. While fueling the immune system with the vital nutrients and bio-active ingredients, identified to have the most significant impact on the modulation and optimization of optimal immune function.

If I have a medical condition, can I take this product?

Consult a healthcare professional before use if you are pregnant or nursing, have a medical condition or use prescription medications.

Is 23Vitals Non-GMO and Gluten-Free?

Yes, 23Vitals never uses genetically modified ingredients, and it is Gluten-Free.

Does 23Vitals contain Soy?

No, 23Vitals is Soy-Free.

Do you use natural colors in 23Vitals?

Yes, we only use natural colors in all flavors of 23Vitals.

Do you use artificial sweeteners?

While this is often a source of controversy and misinformation, the totality of available scientific evidence and multiple systematic reviews of many studies provide no evidence that they cause harm or increase the risk of diabetes, cardiovascular disease, cancer, or kidney disease. We decided to use a non-caloric sweetener (Sucralose) at a shallow dose to enhance the product's palatability, such that we can appeal to a large group of consumers. Long-term compliance studies have shown that overall flavor profile and sensory appeal significantly impacts how compliant consumers are. We carefully evaluated potential risk with potential benefit and found that the potential benefit from compliant, regular consumption of 23Vitals far outweighed any chance of using a non-nutritive sweetener.

Is this product Vegan?

23Vitals is not Vegan due to two dairy-based functional ingredients (VasoDrive-AP & 23Vitals Immune Factors lactoferrin/colostrum). Therefore, while no overt meat products, dairy-based ingredients are processed using unique technology for fractions that have established health benefits.

Is this ok for children to take?

Keep out of reach of children. For adult use only, unless directed by your healthcare professional.

Is it normal to have a temporary activation of my GI tract, with increased bowel movements?

Occasionally, especially in individuals where the microbiome is not optimized, there may be a temporary or transient response. This may involve, a mild laxative or cramping effect. These are signals that some of the bioactives are remodeling and optimizing the microbiome & gut environment. You can choose to decrease your dose (1/2 serving diluted and consumed over the day) for 5 to 7 days, and then gradually increase to a full serving.

Shipping & Guarantees

Is it safe to order online from your Website?

Yes. We use a 256-bit secure ordering serving, so you are protected the same as if you were ordering from Amazon.com or any other trusted Web site.

What if this product doesn't work for me?

If for any reason at all you are not satisfied with your purchase, just let us know, and our customer support team will assist you with noting the basis for your being unsatisfied and processing a swift refund. YOU are why we created this product; we want you to feel safe and secure - knowing that if you are not happy or satisfied for any reason, you are covered by our 30-Day Money-Back Guarantee.

How long before I get my delivery?

During the checkout process, you will have options on how quickly you'd like to receive 23Vitals. Standard will always be free, but depending on where you live in proximity to our shipping center - know that it may take four to as much as nine days to receive. You will have the option to choose UPS 3 Day Select, which will get 23Vitals to you in 3 business days. You will be able to track your delivery via text or Shop (Shopify's Tracking App) - which we highly recommend as there are many other fantastic Shopify stores to support.

Big Questions Deserve Thorough Answers

Is 23VITALS WADA and USADA compliant?

All ingredients within 23VITALS are WADA / USADA compliant.

It would make a great "recovery hack" for any active MMA or UFC athlete. A great addition to their regimen whether they have an upper respiratory "infection" or not. Even beyond just supporting their immune against seasonal cold/flu.

Keep in mind - your immune system is helping your body recover, heal and work through the dynamics of high-stress activities.

What is the 'bioavailability' of 23VITALS?

There has been some debate or controversy about the "bioavailability" and "bioequivalence" of vitamins, minerals, and active extracts from natural biomass sources (tree bark, seeds, fruits, botanicals, mushrooms, ultrafiltered, cold-pressed dairy peptides, etc.).

The "whole-food" or "natural" source matters for specialty bioactive ingredients, such as Wellmune, ResistAID, VasoDrive-AP, 23V Immune Factors, OptiMSM, Bl-04, and AloeACTIVE, as they are more complex and contain many companion constituents, metabolites & co-factors.

However, other pure molecules such as Ascorbate (Vitamin C), or Methylcobalamin (B12), or Cholecalciferol (Vitamin D3) do not differ in their biological activity or efficacy regardless of whether they were manufactured from fermentation, synthetic processes, or provided as a whole food crude material (e.g., Acerola, Oranges, etc.).

This has been settled with multiple human clinical studies, with gold standard analytical methods. When it comes to Vitamin C, the body treats L-ascorbate identically whether it was synthesized with fermentation methods or extracted purely from acerola.

Moreover, we utilize reputable manufacturers routinely audited for SQF & 21 CFR part 111 cGMP standards and inspected by the FDA. Minerals utilized in 23Vitals are chelated for improved bioavailability, as opposed to metal oxide salts. The copper gluconate has also been included to provide an effective ratio alongside Zinc picolinate (Zinmax) and the L-selenomethionine version...all have been demonstrated to be effectively bioavailable without interference on absorption.

How does the immune system work, and what should I be doing daily to make sure it is working optimally?

There are multiple aspects of modern living "conspiring" to take down our whole body health and organ systems, particularly our immune system, which is chief among them under challenge! Chronic, daily mental stress (home, work, family, etc.), sleep deprivation, digital screen time, under (or over)-exercising, deconditioning or overtraining, the standard American diet, poor stress management: These all drain the vitality from the body, mind, and heart. 23Vitals provides part of the solution by helping to "Re-Vitalize" your Immune System, which talks to every organ system in the body.

Our immune systems are complex by design and necessary to battle the multi-faceted foreign threats within our bodies and our environment—the two significant arms or avenues known as the INNATE arm and the ADAPTIVE arm. The innate component is non-specific and meant to act as a first-line-of-defense to target, detect, and clear molecules recognized as foreign. The non-specific defense mechanisms include immune white blood cells that act as "first-responder role players" that secrete a unique network of chemical messengers in the blood that help with communication, recruitment, and activation of other cells within your body. The immune cells of the innate arm include the natural killer (NK Cell), macrophages, neutrophils, and dendritic cells, while cytokines such as type I and II interferons (IFN), chemokine attractants, fibrinogen, IL-1, IL-2, IL-6, TNF-alpha, and IL-17 help to dictate the response of local and systemic cells throughout the body. 

On the other hand, the adaptive arm identifies and targets particular foreign substances presented to the immune system to mount a coordinated response, distinguishing "self" vs. "unwanted" invaders. T-cells and B-cells are the primary "players" of the adaptive arm. They are responsible for launching either an antibody response driven by B-cells or cell-mediated immunity directed by T-cells to neutralize threats. An essential feature of the adaptive arm is that it can prepare the body for future challenges by developing "memory" and "learning" from prior exposure to the specific foreign substance (i.e., antigen).

One of the major byproducts of a healthy immune response is a robust increase in oxidative stress, free radicals, or reactive oxygen species (ROS) from NADPH oxidase, an enzyme found in hard-working white blood cells that must, in turn, be balanced, neutralized and regulated to maintain optimal health. 

As our immune systems and seasonal environmental challenges are both complex and diverse, we recognized the need for a solution supporting the immune system that is sophisticated and comprehensive to address all relevant aspects of both the innate and adaptive arms. We created 23Vitals to solve this problem. 23Vitals is our response for a natural product formula that harnesses the power of immune cells, cytokines, and other organ systems of the body, such as respiratory, cardiovascular, healthy blood flow in a regulated and coordinated fashion.

A solid bedrock of recommendations to support immune health provided by professional health authorities include: social distancing & hygienic health practices, exercise [moderate to intense, but avoiding chronic overtraining] + high quality, sufficient sleep [7-9 hours], circadian rhythm, and managing light exposure, healthy well-rounded diet with adequate protein, fiber, energy/ calorie balance & essential fatty acids + micronutrients [avoiding extreme hyper or hypocaloric shifts such that can maintain moderately lean body composition, and manage body/adipose mass index].

What type of supplement should I take to support my immune system?

The immune system is highly complex. We have both an innate arm and adaptive arm and signaling chemicals in the blood and tissues known as cytokines and chemokines.

We set out to duplicate what we were already doing for ourselves and our families with a comprehensive product that addresses all the relevant parts of the immune system for total immune support. 

23Vitals is our response for a natural product formula that harnesses the power of immune cells, cytokines, and other organ systems of the body, such as respiratory, cardiovascular, healthy blood flow in a regulated and coordinated fashion.

A healthy & resilient immune system that is functioning optimally can adapt and modulate the magnitude of its response by shifting up or down to the environment. 23Vitals is designed to promote a balanced, regulated, and healthy innate + adaptive arm immune response that is up for a challenge. Simultaneously, tempering the blood cytokine profile and maintaining blood flow, coagulation, respiratory and microbiome/ gut health; a versatile and comprehensive ally in orchestrating optimal immune function.

23Vitals is an orchestrated symphony of naturally occurring "Immune-Potentiating" bioactive ingredients to help train, remodel and rejuvenate the Immune System. 23Vitals has the sophistication of taking all the guesswork out of finding the right nutraceutical immune product because it can help regulate the immune system at a fundamental level. It goes beyond just "supporting," since the immune system is enormously dynamic, generating approximately 6 Million new immune cells every minute…daily. As a result, 23Vitals profoundly impact the immune function by rejuvenating and remodeling the immune system into a more effective and resilient one to empower consumers and their families. 

23Vitals uses four different Immuno-Active ingredient blends organized with a sophisticated treasure trove of bioactive natural compounds to comprehensively prepare, defend & support your healthy immune system, and respond to environmental, immune stressors.

Only "ramping up" the immune system is not what you want to do. 23Vitals uses a practical, sophisticated formulation strategy to help the immune system in a manner proportional to the challenge. Sometimes, that means you want to up-regulate it or activate certain aspects, and sometimes you wish to down-regulate it or apply the brakes to some elements such as the NLRP3 Inflammasome. 

Either way, we are looking to immune-MODULATE, as opposed to boosting or haphazardly stimulating all aspects. The strategy behind 23Vitals was created to allow the body to remain primed and prepared to respond in the best possible way when met with a challenge.

There are so many immune supplements out there; why should I be taking 23Vitals instead?

Most products on the market are limited to addressing one minor component of the immune system but ignore others using conventional ingredients lacking sophistication, depth, and breadth. However, Supercharged Nutraceuticals has crafted 23Vitals to comprehensively address all the immune system's critical pillars and components. Most brands use commodity, conventional ingredients for "immune support" to keep cost-of-goods down while maximizing profit.

We intend to empower and impact as many souls and families as possible with the very best that nutritional immunology has uncovered. 23Vitals utilizes premium, clinically studied ingredients in efficacious doses with a sophisticated strategy. 

The bottom line is you and your loved ones get to benefit from our tireless work to source and secure the very best that immune-potentiating and immune-enhancing ingredients have to offer. 

Therefore, while other products are looking to win on price/cost, we aim to deliver on the sophisticated formulation for optimal efficacy, uncompromising quality, and the most premium raw material ingredient sourcing in addition to value & convenience. 

What makes explicitly 23Vitals the best supplement of its kind?

23Vitals is designed to promote a balanced, regulated, and healthy innate + adaptive arm immune response that is up for a challenge. Simultaneously, tempering the blood cytokine profile and maintaining blood flow, coagulation, respiratory and microbiome/ gut health; a versatile and comprehensive ally in orchestrating optimal immune function.

23Vitals is an orchestrated symphony of naturally occurring "Immune-Potentiating" bioactive ingredients to help train, remodel and rejuvenate the Immune System. 23Vitals has the sophistication of taking all the guesswork out of finding the right nutraceutical immune product because it can help regulate the immune system at a fundamental level. It goes beyond just "supporting," since the immune system is enormously dynamic, generating approximately 6 Million new immune cells every minute…daily. As a result, 23Vitals profoundly impact the immune function by rejuvenating and remodeling the immune system into a more effective and resilient one to empower consumers and their families. 

23Vitals uses four different Immuno-Active ingredient blends organized with a sophisticated treasure trove of bioactive natural compounds to comprehensively prepare, defend & support your healthy immune system, and respond to environmental, immune stressors.

Only "ramping up" the immune system is not what you want to do. 23Vitals uses a practical, sophisticated formulation strategy to help the immune system in a manner proportional to the challenge.

Where does 23VITALS land within the 'Synthetic' vs. 'Natural or Whole-Food' conversation?

Although the ingredients in 23Vitals nutritional supplement products are not necessarily wholly derived from whole foods, many are derived from natural product sources (botanical leaves, fruits, berries, seeds, bark, edible mushrooms, etc.).

Some ingredients are fermented, and some are synthesized, and we select every ingredient for being in the optimal form based on the best available scientific evidence. These synthetic nutrients are bio-identical and used by the body in the same way as naturally derived ingredients – whether natural or synthetic – and every ingredient is tested to ensure it meets its stringent specifications for identity, purity, and potency.

How does 23VITALS ensure that each ingredient is tested for identity, purity , and potency?

We're proud that all ingredients are tested 3x for identity, purity, and potency using analytical methods accepted by USP, GLP, and AOAC standards. They are held in quarantine before being released into production.

They are also tested throughout the process along the supply chain, and finally, before releasing labeled, packaged finished products for sale. This includes Vitamin C (it includes testing for heavy metals, toxic impurities, residual solvents).

There has been some debate or controversy about the "bioavailability" and "bio-equivalence" of vitamins, minerals, and active extracts from natural biomass sources (tree bark, seeds, fruits, botanicals, mushrooms, ultra-filtered, cold-pressed dairy peptides, etc.).

The "whole-food" or "natural" source matters for specialty bioactive ingredients, such as Wellmune, ResistAID, VasoDrive-AP, 23V Immune Factors, OptiMSM, Bl-04, and AloeACTIVE, as they are more complex and contain many companion constituents, metabolites & co-factors.

However, other pure molecules such as Ascorbate (Vitamin C), or Methylcobalamin (B12), or Cholecalciferol (Vitamin D3) do not differ in their biological activity or efficacy regardless of whether they were manufactured from fermentation, synthetic processes, or provided as a whole food crude material (e.g., Acerola, Oranges, etc.).

This has been settled with multiple human clinical studies, with gold standard analytical methods. When it comes to Vitamin C, the body treats L-ascorbate identically whether it was synthesized with fermentation methods or extracted purely from acerola.

Moreover, we utilize reputable manufacturers routinely audited for SQF & 21 CFR part 111 cGMP standards and inspected by the FDA. Minerals utilized in 23Vitals are chelated for improved bioavailability, as opposed to metal oxide salts. The copper gluconate has also been included to provide an effective ratio alongside Zinc picolinate (Zinmax) and the L-selenomethionine version...all have been demonstrated to be effectively bioavailable without interference on absorption.

Does 23VITALS contain enough Vitamin D?

Regarding Vitamin D3. Of course, we can get more aggressive, but 4,000 IU is the "TUL" (Tolerable Upper Limit per Inst. Of Medicine).

There is more analysis that goes into the doses we chose.

"4000 IU represents the TUL. The TUL should not be confused with the recommended dose. It is possible that the TUL is less in older people, those with impaired renal function, or those who take calcium supplements."

Also, while we have been more aggressive clinically and recommending 8,000 to 15,000 IU under specific conditions to individuals, and for some folks even higher, we also need to be considering that most people are also getting Vit D from other sources/ supps.

Finally, it is generally accepted that every 1,000 IU of D3 will raise blood levels of 25-OH Vit D by 5-7ng/mL. So, 4,000 IU will reliably move someone from a level of say 15-25ng/mL into an "optimal" Vit D status of 40-45ng/mL within 2-4 weeks.

What if I have a sensitivity to MSM?

For anyone with sulfite sensitivity, clinical doses of MSM may trigger a headache. However, these effects are rare, and the overall benefit + safety profile of OptiMSM make it a worthy bioactive ingredient in 23Vitals.

How many immune cells does our immune system generate daily?

All of our blood cells—both red (AKA oxygen-transporting erythrocytes) and white (immune/disease-fighting leukocytes)—are generated from stem cells that reside inside the marrow of our bones.

All in all, these stem cells give rise to over a dozen different subsets of immune cells (e.g., Neutrophils, Basophils, Eosinophils, Monocytes/Macrophages, Natural Killer Cells, Dendritic Cells, CD8+ Cytotoxic T Cells, CD4+ T-helper Cells, T-suppressor Cells, B-cells/ Plasma Cells, etc.)

All together, >100 Billion Immune Cells Generated daily.

Some accounts claim 10-50 Billion generated daily.

In the human adult, the bone marrow produces all of the red blood cells, 60–70 percent of the white cells (i.e., the granulocytes), and all platelets.

The lymphatic tissues, particularly the thymus, the spleen, and the lymph nodes, produce the lymphocytes (comprising 20–30 percent of the white cells).

The reticuloendothelial tissues of the spleen, liver, lymph nodes and other organs produce the monocytes (4–8 percent of the white cells).

Will I be getting the proper Daily Value (DV%) required for optimal immune function - or will I need to take additional supplementation?

Regarding the Daily Value (DV%), this is a source of confusion for many. Keep in mind that the DVs are what the U.S. Government (and many agencies) has determined is the amount just above what is needed to keep from developing a specific nutrient-deficiency disease, such as scurvy from being deficient in vitamin C. So, 23Vitals has utilized doses of vitamin C and D3 that current evidence suggests will OPTIMIZE the various arms & functions of the immune system, while still staying well below the established "Tolerable Upper Limits" of daily supplementation.

Yes, we expect our customers to be attempting to follow a balanced, whole-food, nutrient-rich diet.

These doses are still regarded as safe even in the presence of a healthy background diet.

Where can I learn more about the human clinical trials that support some of these key ingredients within 23VITALS?

23Vitals is anchored by clinically studied ingredients across many populations, various age ranges from children through seniors, with a significant focus on immune relevant biomarkers and endpoints. Over 50 human clinical trials support the critical ingredients in 23Vitals + other ingredients with promising cell studies and animal preclinical demonstrating rock-solid scientific rationale.

WELLMUNE b-1,3/1,6 glucan

De Marco Castro E, Calder PC, Roche HM. (2020) b-1,3/1,6 glucans and Immunity: State of the Art and Future Directions. Molecular Nutrition and Food Research, https://doi.org/10.1002/mnfr.201901071.

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McFarlin BK, Venable AS, Carpenter KC, Henning AL, Ogenstad S. (2017) Oral Supplementation with Baker's Yeast Beta Glucan Is Associated with Altered Monocytes, T Cells and Cytokines following a Bout of Strenuous Exercise. Frontiers in Physiology 8:786.

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ResistAID/ Larch Arabinolgalactan

Riede L, Grube B, Gruenwald J. Larch arabinogalactan effects on reducing incidence of upper respiratory infections. Curr Med Res Opin. 2013 Mar;29(3):251-8. doi: 10.1185/03007995.2013.765837. Epub 2013 Jan 22. PMID: 23339578.

Udani JK, Singh BB, Barrett ML, Singh VJ. Proprietary arabinogalactan extract increases antibody response to the pneumonia vaccine: a randomized, double-blind, placebo-controlled, pilot study in healthy volunteers. Nutr J. 2010 Aug 26;9:32. doi: 10.1186/1475-2891-9-32. PMID: 20796315; PMCID: PMC2939641.

Udani JK. Immunomodulatory effects of ResistAid™: A randomized, double-blind, placebo-controlled, multidose study. J Am Coll Nutr. 2013;32(5):331-8. doi: 10.1080/07315724.2013.839907. PMID: 24219376; PMCID: PMC3856471.

N-acetylcysteine 

Tse H.N., Tseng C.Z.S. Update on the pathological processes, molecular biology, and clinical utility of N-acetylcysteine in chronic obstructive pulmonary disease. Int. J. Chron. Obstruct. Pulmon. Dis. 2014;9:825–836. doi: 10.2147/COPD.S51057.

Pirabbasi E., Shahar S., Manaf Z.A., Rajab N.F., Manap R.A. Efficacy of Ascorbic Acid (Vitamin C) and/N-Acetylcysteine (NAC) Supplementation on Nutritional and Antioxidant Status of Male Chronic Obstructive Pulmonary Disease (COPD) Patients. J. Nutr. Sci. Vitaminol. (Tokyo) 2016;62:54–61. doi: 10.3177/jnsv.62.54. 

Stey C., Steurer J., Bachmann S., Medici T.C., Tramèr M.R. The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review. Eur. Respir. J. 2000;16:253–262. doi: 10.1034/j.1399-3003.2000.16b12.

***In total, 300 clinical studies (291 clinical trials) of NAC are listed in ClinicalTrials.gov [48] in April 2019

VasoDrive-AP (lactotripeptides)

Martin Foltz, Evelyne E. Meynen, Veronique Bianco, Chris van Platerink, Thea M. M. G. Koning, Joris Kloek, Angiotensin Converting Enzyme Inhibitory Peptides from a Lactotripeptide-Enriched Milk Beverage Are Absorbed Intact into the Circulation, The Journal of Nutrition, Volume 137, Issue 4, April 2007, Pages 953–958.

Chanson-Rolle A, Aubin F, Braesco V, Hamasaki T, Kitakaze M. Influence of the Lactotripeptides Isoleucine-Proline-Proline and Valine-Proline-Proline on Systolic Blood Pressure in Japanese Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS One. 2015 Nov 4;10(11):e0142235. doi: 10.1371/journal.pone.0142235. PMID: 26536628; PMCID: PMC4633157.

Fekete ÁA, Givens DI, Lovegrove JA. Casein-derived lactotripeptides reduce systolic and diastolic blood pressure in a meta-analysis of randomised clinical trials. Nutrients. 2015 Jan 20;7(1):659-81. doi: 10.3390/nu7010659. PMID: 25608938; PMCID: PMC4303860.

Guang C, Phillips RD, Jiang B, Milani F. Three key proteases--angiotensin-I-converting enzyme (ACE), ACE2 and renin--within and beyond the renin-angiotensin system. Arch Cardiovasc Dis. 2012 Jun-Jul;105(6-7):373-85. doi: 10.1016/j.acvd.2012.02.010. Epub 2012 Jun 15. PMID: 22800722; PMCID: PMC7102827.

Bl-04 (Bifidobacterium lactic strain 04 from Howaru/ Dupont):

West NP, Horn PL, Pyne DB, Gebski VJ, Lahtinen SJ, Fricker PA, Cripps AW. Probiotic supplementation for respiratory and gastrointestinal illness symptoms in healthy physically active individuals. Clin Nutr. 2014 Aug;33(4):581-7. doi: 10.1016/j.clnu.2013.10.002. Epub 2013 Oct 10. PMID: 24268677.

Turner RB, Woodfolk JA, Borish L, et al. Effect of probiotic on innate inflammatory response and viral shedding in experimental rhinovirus infection - a randomised controlled trial. Benef Microbes. 2017;8(2):207-215. doi:10.3920/BM2016.0160

OptiMSM (Methylsulfonylmethane)

Barrager E., Schauss A.G. Methylsulfonylmethane as a treatment for seasonal allergic rhinitis: Additional data on pollen counts and symptom questionnaire. J. Altern. Complement. Med. 2003;9:15–16. doi: 10.1089/107555303321222874.

Barrager E., Veltmann J.R.J., Schauss A.G., Schiller R.N. A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis. J. Altern. Complement. Med. 2002;8:167–173. doi: 10.1089/107555302317371451. 

Hewlings S, Kalman DS. Evaluating the Impacts of Methylsulfonylmethane on Allergic Rhinitis After a Standard Allergen Challenge: Randomized Double-Blind Exploratory Study. JMIR Res Protoc. 2018;7(11):e11139. Published 2018 Nov 29. doi:10.2196/11139

van der Merwe M, Bloomer RJ. The Influence of Methylsulfonylmethane on Inflammation-Associated Cytokine Release before and following Strenuous Exercise. J Sports Med (Hindawi Publ Corp). 2016;2016:7498359. doi:10.1155/2016/7498359

Kalman DS, Feldman S, Scheinberg AR, Krieger DR, Bloomer RJ. Influence of methylsulfonylmethane on markers of exercise recovery and performance in healthy men: a pilot study. J Int Soc Sports Nutr. 2012;9(1):46. Published 2012 Sep 27. doi:10.1186/1550-2783-9-46

Withee ED, Tippens KM, Dehen R, Tibbitts D, Hanes D, Zwickey H. Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial. J Int Soc Sports Nutr. 2017;14:24. Published 2017 Jul 21. doi:10.1186/s12970-017-0181-z

Debbi E.M., Agar G., Fichman G., Ziv Y.B., Kardosh R., Halperin N., Elbaz A., Beer Y., Debi R. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: A randomized controlled study. BMC Complement. Altern. Med. 2011;11:50. doi: 10.1186/1472-6882-11-50

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